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KMID : 0391419960060010001
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Korean Journal of Lipidology
1996 Volume.6 No. 1 p.1 ~ p.12
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Relationships between ω6/ω3 fatty Acid Compositions, Vitamin E, Minerals and Antioxidant Enzymes
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이선경
정은정/김수연/이종호/이양자
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Abstract
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While there are many benificial effects of polyunsaturated fatty acids it has been thought that long-term ingestion of φ3 and φ6 fatty acids can promote damage of cell membrane, disturbance of cell function and aging by forming peroxidants and
free
radicals. The effects of dietary φ3 and φ6 fatty acids and different levels of vitamin E on the rat liver antioxidant system was investigated.
Sprague Dawley rats were fed experimental diets throughout gestation and after birth the same diets were given to the off springs until 16 weeks old. Experimental diets consist of corn oil(CO: source of φφ6, C18:2), perilla oil(PO: source of
φ3,
C18:3) and fish oil(FO: source of long chain φ3, C20:5 and C22:6). Each of these 3 diets was supplemented with 1,000 IU/kg of vitamin E(CE, PE, FE group). At 16 weeks ①the concentration of MDA, ②specific activities of Cu, Zn-superoxide
dismutase
(SOD), Mn-SOD & total SOD and glutathione peroxidase (GSH-PX) and ③the concentrations of copper(Cu), Zine(Zn) and manganese(Mn) were measured.
The concentration of MDA was the highest in the FO group and the lowest in the CO group (P<0.05). specific activities of antioxidant enzymes, GSH-Px SOD were the lowest in the FO group. This indicates that the more the dietary fatty acids
unsaturated,
the more the lipid peroxidation occurrs.
When the diets were supplemented with 1,000IU/Kg diets of vitamin E, the concedntration of MDA decreased significantly, the activities of Mn-SOD tended to increase and that of Cu, zn-SOD significantly decreased compared to the group without
vitamin
E
supplementation. This may be related to the fact that Mn-SOD is located in mitochondrial matrix whereas Cu, Zn-SOD is locatedin mitochondrial membrane and cytosol.
The concetration of Cu, Zn and Mn showed no significant differences among experimental groups. However these concentrations tended to increase when vitamin E was supplemented.
In conclusion, long term consumption of φ3 fatty acids can lead to admage of antioxidant systems and it can be prevented by supplementation of antioxidant vitamin, such as vitamin E.
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KEYWORD
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